In vitro toxicological study reveals DNA damage detection in CHO-K1 cells exposed to tannery effluents, indicating the comet assay's utility for monitoring heavy metal contamination.
The comet assay has been described as an efficient tool for the detection of changes in the DNA molecule of cells exposed to contaminating agents in vivo and in vitro. The possible environmental contamination due to the persistence of chromium residues from tannery effluents was determined in the waters of the “Córrego dos Bagres” stream, Municipal district of Franca/SP, by the comet assay on CHO-K1 cells. Water samples were collected during the four seasons of the year 2001 at three distinct stations along the river. The data suggest that the comet test showed good sensitivity for the environmental monitoring of these waters and indicated that this test can be efficient for the determination of the quality of waters contaminated with effluents containing heavy metal residues such as chromium.
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Matsumoto et al. (2003) studied this question.
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