Murine transgenic models provide insights into how alterations in the cardiac conduction system and channelopathies contribute to lethal arrhythmias and sudden cardiac death.
Should not alter clinical arrhythmia management; extends murine conduction system evidence but leaves human translation open.
The cardiac conduction system (CCS) is composed of a group of myocardial tissues that control and coordinate the heart. Alterations in the CCS - especially in the His-Purkinje system, have been identified as a major cause of lethal arrhythmias. Unstable arrhythmias secondary to channelopathies significantly increase the risk of sudden cardiac death (SCD). SCD is a major contributor to mortality in industrialized countries, and most cases of SCD in the young are related to inherited ion channel diseases. In this paper, we review a series of studies with murine transgenic models that revealed that some arrhythmias are associated with the CCS and may lead to SCD.
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Aránega et al. (2012) studied this question.
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