Retrospective cohort study reveals risk factors for acute and chronic kidney injury in adults with acute glomerulonephritis, highlighting key clinical markers.
Key Points
To identify clinical characteristics and risk factors associated with acute and chronic disease severity in adult patients with acute glomerulonephritis.
Retrospective cohort study analyzing adult patients diagnosed with acute glomerulonephritis (AGN) between January 2001 and December 2023 from a Real World Data database (N=1,002 included from 6,795 diagnosed).
Multivariable logistic regression and sensitivity analysis with modified Poisson regression were performed to evaluate predictors of acute severity (within 30 days) and chronic progression (at 1 year).
Stage ≥1 acute kidney injury within 30 days was significantly associated with age (aOR 1.04, 95% CI 1.03–1.05), maximum dipstick occult blood (aOR 1.24, 95% CI 1.06–1.45), and maximum dipstick proteinuria (aOR 1.61, 95% CI 1.39–1.87).
Chronic kidney disease progression at 1 year was associated with age (aOR 1.02, 95% CI 1.01–1.04), dipstick proteinuria (aOR 1.86, 95% CI 1.59–2.19), hypertension (aOR 1.55, 95% CI 1.08–2.22), and maximum serum creatinine ≥2 mg/dL (aOR 3.02, 95% CI 1.79–5.11).