Chemical synthesis study demonstrates rhodium-catalyzed (4 + 1) cycloaddition of strained cyclobutenes and carbon monoxide, highlighting reaction mechanisms and regioselectivity.
We hypothesized that the cyclobutenes in 1H-cyclobuta[de]naphthalenes (CBNs) could have high strains and can take part in cycloadditions. This was proven by experiments showing that, under Rh catalysis, CBNs and CO can achieve (4 + 1) cycloaddition. Quantum chemical calculations have been utilized to analyze the detailed reaction mechanism and regiochemistry of this (4 + 1) reaction.
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Yu et al. (2026) studied this question.
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