The modified Wecker technique can classify vaccine-related poliovirus strains, but some wild-type strains in Japan are antigenically indistinguishable from the vaccine strain, necessitating additional testing methods.
Antigenic classification alone may misclassify wild poliovirus strains; leaves open the need for supplementary testing methods in surveillance.
The intratypic serodifferentiation test of type 3 polioviruses was carried out with the modified Wecker technique using anti-Sabin 3 rabbit sera. Thirty-four vaccine-related and 28 nonvaccine-related strains were examined. Of the 34 vaccine-related strains, 30 were classified as vaccine-like, 3 as intermediate, and one as nonvaccine-like. Out of 28 wild strains tested, 12 were classified as nonvaccine-like, 7 as intermediate, and 9 as vaccine-like.These results showed that with the modified Wecker technique, vaccinerelated virus could be classified as vaccine-like, whereas some of the wild type 3 poliovirus isolated in Japan were indistinguishable antigenically from the Sabin type 3 vaccine virus. For the more conclusive differentiation of type 3 polio strains, it was needed to carry out comparative studies of these strains by the McBride and modified Wecker techniques.
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Soda et al. (1969) studied this question.
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