Clinical Dermatology

Skin Eruptions Associated with DrugsThe organization, in recent years, of central committees such as the Safety of Drugs Committee in Great Britain, has enabled a great deal of information to be collected about the nature of different drug reactions.129 Although the incidence of drug reactions cannot be assessed accurately, it is known that antibiotics, sedatives and tranquilizers are most frequently implicated in the United States and Britain, since they are, by far, the most frequently used. Penicillin, warfarin and imipramine, however, when evaluated on a reaction-to-dose basis, were the most common offenders.130The frequency of reactions to drugs as . . .