Key result
Cardiac involvement is frequent in newly diagnosed pulmonary TB patients, and early pericardial changes may be reversed after 6 months of anti-TB treatment (P=0.8 for an unspecified comparison).
Why the study?
Subclinical cardiovascular manifestations of tuberculosis are poorly documented in countries with a high burden of tuberculosis and HIV.
Does anti-TB treatment improve echocardiographic signs of cardiovascular involvement in patients with pulmonary TB?
Cohort
Yes
Does anti-TB treatment improve echocardiographic signs of cardiovascular involvement in patients with pulmonary TB?
Echocardiographic screening in newly diagnosed TB patients reveals frequent cardiac involvement that may be reversible with standard anti-TB treatment.
Background: Tuberculosis (TB) is the leading cause of death among people with HIV and a major global health challenge. Subclinical cardiovascular manifestations of TB are poorly documented in high TB and HIV burden countries. Objectives: The purpose of this study was to quantify the prevalence of cardiovascular involvement in TB patients and investigate changes after completion of anti-TB treatment. Methods: HIV-positive and HIV-negative patients diagnosed with pulmonary TB between October 2022 and November 2023 were enrolled from 2 tertiary care hospitals in Zambia and South Africa. Standardized transthoracic echocardiography (TTE) was conducted at TB diagnosis and after 6 months of anti-TB treatment. Cross-sectional and longitudinal analyses assessed pericardial effusion, thickening, or calcification, with and without signs of pericardial constriction. Conclusions: Cardiac involvement is frequent in newly diagnosed TB patients. Early pericardial changes may be reversed with anti-TB treatment. Echocardiographic screening facilitates early detection and timely management of cardiovascular involvement in TB patients.
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Samim et al. (2024) conducted a cohort in Pulmonary Tuberculosis. Anti-TB treatment vs. Baseline (at TB diagnosis) was evaluated on Prevalence of cardiovascular involvement (pericardial effusion, thickening, or calcification, with and without signs of pericardial constriction) (p=0.8). Cardiac involvement is frequent in newly diagnosed pulmonary TB patients, and early pericardial changes may be reversed after 6 months of anti-TB treatment (P=0.8 for an unspecified comparison).
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