Laboratory study demonstrates Lactiplantibacillus plantarum decreases permeability in intestinal organoids, indicating protection via endocannabinoidome signaling.
Lactiplantibacillus plantarum strains improve transepithelial permeability and concomitantly increase the levels of eCBome mediators in murine small intestine epithelial organoids. Pharmacological elevation of NAE or 2-MAG levels enhances the expression of intestinal epithelial barrier genes and reduces the transepithelial permeability of murine small intestine epithelial organoids, suggesting that L. plantarum may exploit eCBome signaling to exert its beneficial effects.
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Allam‐Ndoul et al. (2025) studied this question.
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