Why the study?
Does locally produced insulin-like growth factor II promote the development of atherosclerosis in a mouse model?
Does locally produced insulin-like growth factor II promote the development of atherosclerosis in a mouse model?
Locally produced insulin-like growth factor II plays a pivotal atherogenic role in vivo, as demonstrated by reduced lesion size in knockout models and spontaneous intimal thickening in transgenic models.
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May support IGF-II as atherosclerosis target in mice; leaves open human relevance and need for clinical studies.
Zaina et al. (2002) studied this question.
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