Key result
Estimated pulse wave velocity (ePWV) demonstrated a strong independent association with directly measured carotid-femoral pulse wave velocity (β = 0.599) and brachial-ankle pulse wave velocity (β = 1.342).
Why the study?
Indirect estimates of pulse wave velocity have been proposed as an alternative for PWV assessment in clinical practice, but their validity and clinical applicability remain uncertain.
Do indirect 24-hour blood pressure arterial stiffness indexes (ePWV, 24h-PP, EVAAS) accurately correlate with directly measured pulse wave velocity in adults?
Population
4,206 individuals from Brazil, Greece, Korea, and Australia
Comparison
Indirect arterial stiffness measures (ePWV, 24h-PP, EVAAS) vs directly measured cf-PWV and/or ba-PWV
Design
Multicentre international individual patient data analysis
Authors
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Supports ePWV validity as noninvasive surrogate; leaves open outcome studies before clinical adoption in hypertension.
Observational (n=4,206)
Yes
Do indirect 24-hour blood pressure arterial stiffness indexes (ePWV, 24h-PP, EVAAS) accurately correlate with directly measured pulse wave velocity in adults?
Effect estimate: β = 0.599 (95% CI 0.495 to 0.703)
p-value: p=< 0.001
Estimated pulse wave velocity (ePWV) derived from 24-hour ambulatory blood pressure monitoring can serve as a valid non-invasive surrogate marker for arterial stiffness, particularly in individuals without major cardiometabolic comorbidities.
Kakaletsis et al. (2025) conducted an observational in Hypertension and cardiovascular risk (n=4,206). Estimated pulse wave velocity (ePWV) was evaluated on Association between estimated pulse wave velocity (ePWV) and directly measured carotid-femoral pulse wave velocity (cf-PWV) (β = 0.599, 95% CI 0.495 to 0.703, p=< 0.001). Estimated pulse wave velocity (ePWV) demonstrated a strong independent association with directly measured carotid-femoral pulse wave velocity (β = 0.599) and brachial-ankle pulse wave velocity (β = 1.342).
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