Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for proliferative diseases like cancer.
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Mbikay et al. (1993) studied this question.
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