The CYP3A4-NADPH-cytochrome P450 reductase system specifically participates in the metabolic activation and nitric oxide formation from isosorbide dinitrate in the heart.
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Animal data implicate CYP3A4 in cardiac ISDN bioactivation; leaves open any relevance to human nitrate therapy.
Minamiyama et al. (1999) studied this question.
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