Osteogenesis Imperfecta and other Bone Disorders in the Differential Diagnosis of Unexplained Fractures

Over the past 14 years I have been asked to investigate 86 children with unexplained fractures in whom non-accidental injury had been suspected. In each case at least one professional observer, often a guardian ad litem, had felt that there was doubt about the accuracy of that diagnosis. The group therefore represents a selected population. Among these patients several clear patterns have emerged. The most common findings were osteogenesis imperfecta and a newly recognized group oftemporary brittle bone diseases.