Why the study?
Does V-ATPase inhibition by bafilomycin A1 prevent neointimal myofibroblast growth in cultured human saphenous vein segments?
Does V-ATPase inhibition by bafilomycin A1 prevent neointimal myofibroblast growth in cultured human saphenous vein segments?
V-ATPase inhibition selectively induces apoptosis and inhibits growth in myofibroblasts, suggesting a potential therapeutic target to prevent neointimal hyperplasia in vein grafts.
Selective myofibroblast apoptosis by bafilomycin A1 is hypothesis-generating for vein graft hyperplasia; does not support clinical translation.
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Otani et al. (2000) studied this question.
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