Key result
Low diastolic wall strain is independently associated with increased left ventricular end-systolic volume (OR 1.122) and left ventricular mass index (OR 1.091), suggesting early adverse remodeling precedes functional changes.
Cross-Sectional (n=349)
No
Decreased diastolic wall strain is associated with adverse left ventricular remodeling and subtle systolic/diastolic changes even in patients with normal diastolic function, suggesting it may serve as an early marker of cardiac dysfunction.
May flag early remodeling on echo; leaves open whether it improves risk stratification or warrants prospective validation.
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Kang et al. (2014) conducted a cross-sectional in Normal left ventricular diastolic function (n=349). Low diastolic wall strain vs. High diastolic wall strain was evaluated on Association of left ventricular end-systolic volume with low diastolic wall strain (OR 1.122, 95% CI 1.071-1.166, p=<0.001). Low diastolic wall strain is independently associated with increased left ventricular end-systolic volume (OR 1.122) and left ventricular mass index (OR 1.091), suggesting early adverse remodeling precedes functional changes.
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