Key result
Polymorphisms in the Insig-1 gene, specifically the GG genotype at A4366G and CC genotypes at T4534C and T5001C, were associated with better growth and carcass traits in Qinchuan cattle.
Why the study?
Are polymorphisms in the Insig-1 gene associated with growth and carcass traits in Qinchuan cattle?
Observational (n=215)
Are polymorphisms in the Insig-1 gene associated with growth and carcass traits in Qinchuan cattle?
Polymorphisms in the Insig-1 gene are associated with growth and carcass traits in Qinchuan cattle, suggesting potential utility for marker-assisted selection in beef breeding.
May inform marker-assisted selection in Qinchuan cattle; leaves open validation across breeds before broader application.
The insulin-induced gene 1 (Insig-1) is a regulator of lipid metabolism and plays an important role in the sterol-mediated regulation of SREBP, SCAP and HMG-CoA reductase. We used PCR-RFLP and DNA sequencing to detect polymorphisms of the Insig-1 gene in 215 individuals of the Qinchuan cattle breed. Four SNPs [4366(A>G), 4534(T>C), 5001(T>C), and 5235(G>A)] were indentified. The association of the genetic viariation with growth and carcass traits (body length, withers height, hip width, slaughter weight, and carcass weight) was analyzed. The individuals with better performance had the GG genotype at locus A4366G, and CC genotypes at locus T4534C and locus T5001C. These could be used for beef cattle breeding improvement in China. Additionally, linkage disequilibrium analysis reflected that all mutations were in low linkage disequilibrium with each other. We concluded that polymorphisms in the Insig-1 gene are associated with growth and carcass traits and could be used for marker-assisted selection and management in beef cattle breeding programs.
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Liu et al. (2012) conducted an observational in Growth and carcass traits (n=215). Insig-1 gene polymorphisms vs. Other genotypes was evaluated on Growth and carcass traits (body length, withers height, hip width, slaughter weight, and carcass weight). Polymorphisms in the Insig-1 gene, specifically the GG genotype at A4366G and CC genotypes at T4534C and T5001C, were associated with better growth and carcass traits in Qinchuan cattle.
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