A novel asymmetric 3-furyl addition of (3-furyl)Ti(O(i)Pr)(3) to ketones in the presence of 10 mol % (S)-BINOL is reported. The catalytic system works excellently for aromatic ketones, alpha- or beta-halophenones, alpha,beta-unsaturated ketones, and acetylfuran, affording products in high yields with excellent enantioselectivities of up to 97% ee.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: