Prostaglandins and Asthma

Editorial1 June 1973Prostaglandins and AsthmaCHARLES W. PARKER, M.D., DIXIE E. SNIDER, M.D.CHARLES W. PARKER, M.D.Search for more papers by this author, DIXIE E. SNIDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-963 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prostaglandins are 20-carbon, aliphatic, monocarboxylic acids with a five-membered ring and one or more unsaturated double bonds. They are found throughout the plant and animal kingdom and are present in virtually every tissue of the human body, but there is little information on their normal physiological function or their role in human disease. It has been known since the early 1930s that prostaglandins have potent effects on smooth-muscle tone (1). In the past decade these compounds have been shown to be in the human lung (2, 3) and to be capable of contracting or dilating bronchial muscle (4-7). Inevitably...References1. VON EULER U: On the specific vasodilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin). J Physiol (Lond) 88:213-234, 1937 CrossrefGoogle Scholar2. ANGGÅRD E: The isolation and determination of prostaglandins in lungs of sheep, guinea pig, monkey and man. Biochem Pharmacol 14:1507-1516, 1965 CrossrefMedlineGoogle Scholar3. KARIMSANDLERWILLIAMS SME: Distribution of prostaglandins in human tissues. Br J Pharmacol Chemother 31:340-344, 1967 CrossrefMedlineGoogle Scholar4. SHEARD P: The effects of prostaglandin E1 on isolated bronchial muscle from man. J Pharm Pharmacol 20:232-233, 1968 CrossrefMedlineGoogle Scholar5. SWEATMANCOLLIER WH: Effects of prostaglandins on human bronchial muscle. 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ANGGARDLARSSONSAMUELSSON ECB: The distribution of 15-hydroxy prostaglandin dehydrogenase and prostaglandin-D13 reductase in tissues of swine. Acta Physiol Scand 81:396-404, 1971 CrossrefMedlineGoogle Scholar29. SAMTERBEERS MR: Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med 68: 975-983, 1968 LinkGoogle Scholar30. SMITH A: Response of aspirin-allergic patients to challenge by some analgesics in common use. Br Med J 2:494-296, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine The Washington University School of Medicine St. Louis Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHyperresponsiveness of the Extrathoracic Airway in Patients with Captopril-lnduced CoughPharmacological Application of Prostaglandins, Their Analogues, and Their Inhibitors in ObstetricsSevere acute asthma and the menstrual cycleVitamin C and AirwaysSK&F 88046: Inhibition of thromsoxane-induced bronchoconstriction in anesthetized dogsEffect of histamine, acetylcholine and compound 48/80 on bronchoconstriction and release of eicosanoids in the dogPlasma prostaglandin activities in some immuno-inflammatory diseasesMediators of AnaphylaxisEndocrine Functions of the LungSPONTANEOUS ACTIVITY IN THE TRACHEA OF DOGS TREATED WITH INDOMETHACIN: AN EXPERIMENTAL MODEL FOR ASPIRIN-RELATED ASTHMASignification des tests cutanés a la poussière de maisonStimulation of afferent vagal endings in the intrapulmonary airways by prostaglandin endoperoxide analoguesNew Method for Evaluating Bronchomotor and Bronchosecretory Activities: Effects of Prostaglandins and AntigenThe in vitro effect of toluene diisocyanate on lymphocyte cyclic adenosine monophosphate production by isoproterenol, prostaglandin, and histamineTHE EFFECTS OF SOME BRONCHODILATOR AND ANTI-INFLAMMATORY DRUGS ON PROSTAGLANDIN F 2a -INDUCED CONTRACTION OF GUINEA-PIG ISOLATED TRACHEARespiratory System (General Introduction)Stimulation of ‘irritant’ receptors and afferent C-fibres in the lungs by prostaglandinsAllergy and Clinical Immunology: An Annotated Bibliography of Recent Literature References to Journal Articles and Other PapersBronchoconstriction and pulmonary hypertension during abortion induced by 15-methyl-prostaglandin F2αBronchopulmonary pharmacology of some prostaglandin endoperoxide analogs in the dogAspirin and exercise-induced asthmaThe Current Status of Prostaglandins and the LungsBronchopulmonary effects of prostaglandin F2α and three of its metabolites in the dogHuman SpermhormoneACETYLSALICYLIC ACID INTOLERANCEAllergic Emergencies 1 June 1973Volume 78, Issue 6Page: 963-965KeywordsAcidsAsthmaLungsMusclesProstaglandins Issue Published: 1 June 1973 PDF DownloadLoading ...