Mechanistic study reveals a stromal-ILC2 positive feedback loop maintains type 2 immune cells in visceral adipose tissue, highlighting a key axis in fat tissue homeostasis.
Type 2 immune cells are key to the maintenance of healthy adipose tissue, however the cues responsible for the establishment and maintenance of adipose type two immune cells remain unclear. Rana et al. report a specialized stromal cell produces interleukin-33 (IL-33) that activates group 2 innate lymphoid cells (ILC2s). Activated ILC2s in turn produce type two cytokines that elicit further IL-33 production by the stroma in a positive feedback loop that maintains the type 2 immune cell network within visceral adipose tissue (VAT).
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Moyat et al. (2020) studied this question.
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