Answers are grounded in this paper and cite their sources.
More than 50% of the [(3)H]thymidine incorporated during short pulses into the DNA of Escherichia coli 15T(-) can be extracted by alkali as high molecular weight DNA. Density gradient centrifugation and digestion with exonuclease I suggest that these large pieces of DNA are composed of newly synthesized DNA attached to pre-existing material at the 3' end of the molecule.
No takes yet. Share an insight, caveat, or question.
Iyer et al. (1970) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: