Antibody Formation in Cases of Lobar Pneumonia Treated With Sulfapyridine

For many years it has been known (1, 2, 3, 4) that at the time of the crisis in lobar pneumonia, or immediately thereafter, an excess of type-specific antibody can be demonstrated in the blood serum of the patient. While this phenomenon is not absolutely invariable, most observers have agreed that it occurs in the great majority of instances. Conversely, in cases going on to a fatal termination, where crisis does not occur, no type-specific antibody can be demonstrated in the patient's serum during the course of the disease. These facts have led to the belief that spontaneous recovery in lobar pneumonia is intimately related to the patient's capacity for producing type-spe-cific antibody in such amount as to react with all