Proteolytic Enterococcus faecalis isolates produced strong inhibitory activity against mutans streptococci in a deferred antagonism test on Columbia agar base medium supplemented with 5% human blood. Hematin was responsible for this inhibitory effect and its formation by the enterococci was dependent upon incubation in the presence of hemoglobin under conditions favourable to protease production.
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James et al. (1987) studied this question.
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