α-Synuclein Gene and Parkinson's Disease

Mihael H. Polymeropoulos et al. (Reports, 27 June 1997, p. [2045][1]) ([1][2]) reported an Ala53Thr mutation in the α-synuclein gene, at the PD-1 locus on chromosome 4q2l-q23 ([2][3]), in a large Italian family and three smaller Greek kindreds with autosomal dominant Parkinson's disease (PD). The