Key result
Viruses, including influenza A and vesicular stomatitis virus, suppress host mRNA nuclear export to impair host cellular antiviral responses.
This review highlights the sophisticated mechanisms by which viruses target host mRNA export factors to evade cellular antiviral responses.
Suggests host mRNA export factors as antiviral targets; extends mechanistic data but leaves open therapeutic validation.
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.
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Kuss et al. (2013) conducted a review in Viral infections. Viral suppression of host mRNA nuclear export was evaluated. Viruses, including influenza A and vesicular stomatitis virus, suppress host mRNA nuclear export to impair host cellular antiviral responses.
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