We describe properties and constructions of constraint-based codes for DNA-based data storage which account for the maximum repetition length and AT/GC balance. Generating functions and approximations are presented for computing the number of sequences with maximum repetition length and AT/GC balance constraint. We describe routines for translating binary runlength limited and/or balanced strings into DNA strands, and compute the efficiency of such routines. Expressions for the redundancy of codes that account for both the maximum repetition length and AT/GC balance are derived.
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Immink et al. (2020) studied this question.
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