Key result
Thoracoscopic biopsy successfully diagnosed tuberculosis as the cause of exudative-constrictive pericarditis in a 31-year-old male after negative laboratory tests.
Why the study?
To present the problems and possibilities of diagnosis and treatment in a patient with resistant exudative-constrictive pericarditis.
Case Report (n=1)
Invasive morphological diagnosis via thoracoscopic biopsy is crucial for diagnosing tuberculous pericarditis when standard laboratory tests and non-invasive imaging are inconclusive.
Answers are grounded in this paper and cite their sources.
May support thoracoscopic biopsy in select inconclusive cases; leaves open prospective validation for tuberculous pericarditis.
PURPOSE: To present the problems and possibilities of diagnostic and treatment in a patient with resistant exudative-constrictive pericarditis. METHODS: The male patient 31 y. was admitted to the clinic due to exudative pericarditis and arthritis of the left knee joint. His medical history periodic febrile fever with a cough, episodes of syncope and atrial fibrillation, treatment with antibiotics and corticosteroids with a temporary effect. RESULTS: No data were received for systemic disease, hypothyroidism, tumors. With CT in both lungs, small areas of fibrosis and lymphadenopathy were identified. Pericardial sheets diffusely thickened. EchoCG shows one liter of pericardial fluid with fibrin. All tests for viruses and tuberculosis are negative. Thoracoscopy was performed. Morphological examination showed tuberculosis granulomas with caseous necrosis. The growth of mycobacteria of tuberculosis from sputum was obtained. Therapy included pyrazinamide, ethambutol, levofloxacin, prednisolone 20 mg / day. Ponce's disease regressed. Due to the increase of constriction, subtotal pericardectomy was performed. CONCLUSION: Tuberculosis is one of the real causes of pericarditis with massive effusion and an outcome in constriction. The negative results of all laboratory tests for tuberculosis do not exclude the diagnosis. It is necessary to use invasive morphological diagnosis, including thoracoscopic biopsy.
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Благова et al. (2020) conducted a case report in Exudative-constrictive pericarditis (n=1). Thoracoscopic biopsy was evaluated on Diagnosis of tuberculosis granulomas with caseous necrosis. Thoracoscopic biopsy successfully diagnosed tuberculosis as the cause of exudative-constrictive pericarditis in a 31-year-old male after negative laboratory tests.
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