Polydipsia and Inappropriate Secretion of Antidiuretic Hormone Associated with Hydrocephalus

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Letters1 November 1975Polydipsia and Inappropriate Secretion of Antidiuretic Hormone Associated with HydrocephalusDANIEL T. PETERSON, M.D., WILLIAM H. MARSHALL, M.D.DANIEL T. PETERSON, M.D., WILLIAM H. MARSHALL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-675_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyponatremic seizures and coma associated with acute psychosis were recently reported in the Annals of Internal Medicine (1).The patient is a 26-year-old white woman with undifferentiated schizophrenia and intermittent compulsive water drinking. Since her prior evaluation documenting episodic inappropriate secretion of antidiuretic hormone (ADH) (1), the patient has been treated for hyponatremic seizures in at least four hospitals in the western United States and Canada. The patient was admitted to Stanford University Hospital, unresponsive with generalized seizures after drinking a large quantity of water. Urinary incontinence not associated with coma had been noted. There were no localizing neurological signs....References1. DUBOVSKY S, GRABON S, and BERTL T: Syndrome of inappropriate secretion of antidiuretic hormone with exacerbated psychosis. Ann Intern Med 79:551-554, 1973 LinkGoogle Scholar2. HOBSON J and ENGLISH J: Self-induced water intoxication. Case study of a chronically schizophrenic patient with physiological evidence of water retention due to inappropriate release of antidiuretic hormone. Ann Intern Med 58:324-332, 1963 LinkGoogle Scholar3. HABENER J, DASHE A, and SOLOMON D: Response of normal subjects to prolonged high fluid intake. J Appl Physiol 19:134-136, 1964 CrossrefMedlineGoogle Scholar4. PICKERING L and HOGAN G: Voluntary water intoxication in a normal child. J Pediatr 78:316-318, 1971 CrossrefMedlineGoogle Scholar5. HOGAN P and WOOLSEY R: Polydipsia associated with occult hydrocephalus. N Engl J Med 277:639-640, 1967 CrossrefMedlineGoogle Scholar6. ANDERSSON B: Polydipsia, antidiuresis and milk ejection caused by hypothalamic stimulation, in The Neurohypophysis, edited by HELLER H. New York, Academic Press, 1957, pp. 131-140 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL T. PETERSON, M.D.; WILLIAM H. MARSHALL, M.D.Affiliations: Departments of Medicine and Radiology Stanford University Medical Center Stanford, California 94305 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeonatal Hyponatremia in the Setting of Untreated Progressive HydrocephalusRapid deterioration of primary fourth ventricular outlet obstruction resulting in syndrome of inappropriate antidiuretic hormone secretionHyponatraemia in patients with normal pressure hydrocephalusSchizophrenic patients with polydipsia and water intoxication more often have a form of schizophrenia first described by KraepelinHyponatraemia in elderly and adult psychiatric inpatientsEffects of water loading in schizophrenic patients with polydipsia-hyponatremia: an MRI pilot studyAtrial natriuretic peptide and arginine vasopressin secretion in schizophrenic patientsManners of Arginine Vasopressin Secretion in Schizophrenic Patients:—With Reference to the Mechanism of Water Intoxication—Long-Term Neuroleptic Toxicity and Mood: Blurring of Diagnostic BoundariesDevelopmental Pharmacokinetics of the Posterior Pituitary HormonesInappropriate secretion of antidiuretic hormone associated with cerebellar and cerebral atrophy 1 November 1975Volume 83, Issue 5 Page: 675-676 Keywords Antidiuretic hormone Coma Epileptic seizures Hydrocephalus Schizophrenia Urinary incontinence ePublished: 1 December 2008 Issue Published: 1 November 1975 PDF downloadLoading ...