Demonstration of Thiosemicarbazide-Induced Convulsions in Rats with Elevated Brain Levels of -Aminobutyric Acid.

This is the authors' abstract. We don't add key points for this paper.

In confirmation of biochemical data for whole brain, injection of thiosemicarbazide produced convulsive seizures in rats concomitantly with decreases in levels of γ-aminobutyric acid in 9 areas of the brain. However, rats injected with both hydroxylamine and thiosemicarbazide had convulsive seizures when levels of γ-aminobutyric acid were either elevated or normal in different areas of brain. Seizures produced by administration of thiosemicarbazide are not related to a generally decreased level of γ-aminobutyric acid in the brain.