the urine contains bacteria and at times pus for years, although there is no constitutional dis- turbance.There is very little danger of the process extending to the kidney, or that it will involve anything more than the superficial lay- ers of the pelvis and bladder.The pathology shows simply a eatarrhal con- dition of the bladder and pelvis of the kidney.Very few autopsies have been made, because the condition is rarely fatal.TREATMENT.The alkaline method of treatment will often suffice to cure the disease.Potassium citrate is cine should be given every three or four days, beginning with a dose of 25,000,000 and increas- ing to 160,000,000.The large doses of hexa- methylenamin should not be continued for more than a week at a time, and then after several days without any treatment, or with alkaline treatment, the hexamethylenamin should be started again at the same maximum dose given before4.The urine should be carefully watched for irritation of the kidney.Local treatment of the bladder is of compar- atively no value, because the infection is not localized in the bladder but involves the whole urinary tract.
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Theodore Ely (1914) studied this question.