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Investigators 1 have found that the incidence of multiple primary malignant tumors in all cases of malignant tumors is about 3%. Of these tumors, roughly half occur simultaneously and half after varying intervals of time. 1a It has been computed 2 that an individual with one malignant tumor is more likely to have, subsequently, more primary malignant tumors than can be accounted for on the basis of chance alone. These multiple lesions may or may not occur in the same organ. The incidence of multiple primary carcinomas of the colon has been estimated to be from 3.5% to 5%, 3 these occurring either simultaneously or at different times. Reports of such cases have been rather numerous 4 and serve to stress the point that palpation of the entire colon should be performed at the time of laparotomy for carcinoma. In two reported cases 5 each patient had four distinct primary
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I. Ridgeway Trimble (1951) studied this question.
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