Use of Busulfan in Myelogenous Leukemia during Pregnancy

EXPERIENCE with the use of busulfan§ during the course of pregnancy is, apparently, extremely limited. A review of the literature disclosed only 1 previous case report, and personal communications with several large clinics have revealed no additional cases. Izumi1 reported the case of a thirty-one-year-old woman whose therapy with busulfan began about three months before conception. She was treated with maintenance therapy throughout pregnancy, and there was no evidence of disturbance of fetal granulopoietic function.Kenis et al.2 reported that the drug caused amenorrhea in a series of patients either during or after treatment, and in 1 young man, gonadal . . .