Key result
A 45-year-old woman with a mucinous ovarian tumor was found to have a coexisting angiosarcoma, highlighting the diagnostic challenge of macroscopic hemorrhagic areas during intraoperative frozen section.
Why the study?
Primary ovarian angiosarcoma is rare and aggressive, with few reported cases and limited data on underlying molecular abnormalities.
Case Report (n=1)
Macroscopic hemorrhagic areas in ovarian mucinous tumors should be carefully evaluated during intraoperative frozen section to avoid missing a diagnosis of angiosarcoma.
BACKGROUND: Angiosarcoma (AS) is a rare and highly aggressive soft tissue disease that most commonly arises in deep soft tissues. There are only a few reported cases of AS involving the ovary and even fewer reports of the underlying molecular abnormalities. Here, we briefly review two cases of primary ovarian AS (oAS) with specific molecular events and immune checkpoints. The clinical features and prognosis of the disease, diagnosis, differential diagnosis, and new treatment approaches are discussed based on a literature review. CASE SUMMARY: gene amplification. MESNA + ADM + IFO + DTIC (MAID) regimen was administered, but stable disease was achieved. The patient died 1 mo later. Case 2: A 41-year-old female patient presented with fatigue, nausea, decreased appetite, and diffuse abdominal pain. On physical examination, the abdomen was distended and a complex cystic mass was palpable in the right pelvic cavity. Pathology revealed primary oAS. MAID chemotherapy was administered and programmed death ligand 1 (PD-L1) staining was performed on the tumor samples. The patient benefited from anti-PD-1 immunotherapy and is alive without any evidence of disease 27 mo off therapy in follow-up. CONCLUSION: Long-term survival benefit for primary oAS can be achieved by alternative therapeutic strategies using pathological indicators to inform treatment.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2023) conducted a case report in Primary ovarian angiosarcoma arising in ovarian mucinous tumor (n=1). Surgical resection and adjuvant chemotherapy was evaluated on Diagnosis and clinical course. A 45-year-old woman with a mucinous ovarian tumor was found to have a coexisting angiosarcoma, highlighting the diagnostic challenge of macroscopic hemorrhagic areas during intraoperative frozen section.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: