Chirally Aminated 2‐Naphthols—Organocatalytic Synthesis of Non‐Biaryl Atropisomers by Asymmetric Friedel–Crafts Amination

Cinchona alkaloids are employed in an organocatalyzed asymmetric Friedel–Crafts amination reaction of 2-naphthols. These amination reactions proceed in high yields with up to 98 % ee and have led to a new class of non-biaryl atropisomer. The rotation barriers of the chiral aminated 2-naphthols have been investigated by experimental and computational methods.