New amphiphilic starch-polyester graft copolymer and chemically modified starch with fatty acid chains were synthesized and then cross-linked with a nontoxic agent, citric acid, in order to obtain hydrogels with a controlled hydrophilicity. They present well-defined pores, a controlled water retention degree and different time ranges for releasing the drug, depending on the synthesis parameters. The new hydrogels may be used in the biomaterials field as matrices for delivering biologically active agents, for coating a surface or a synthetic implant.
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Uliniuc et al. (2012) studied this question.
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