Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrateOriginal Research · 1994 · 191 citations
2. 2Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell diseaseOriginal Research · 2010 · 211 citations
3. 3Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.Original Research · 1999 · 260 citations
4. 4Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrateOriginal Research · 1994 · 212 citations
5. 5Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell AnemiaRCT · 1995 · 2,372 citations