What question did this study set out to answer?

To evaluate the antitumor activity and response patterns of CHOP chemotherapy prior to cranial irradiation in patients with primary central nervous system lymphoma.

September 1, 1994Neurology

Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma

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To evaluate the antitumor activity and response patterns of CHOP chemotherapy prior to cranial irradiation in patients with primary central nervous system lymphoma.
Prospective clinical evaluation of CHOP chemotherapy before planned craniospinal radiotherapy in patients with primary central nervous system lymphoma (N=6).
Radiographic response was measured by changes in contrast-enhancing cross-sectional tumor area after two and four cycles of chemotherapy.
Primary tumor area was reduced by ≥80% in 4 patients and to a lesser extent in 2 patients after two cycles, with complete loss of enhancement in all 3 patients completing four cycles.
Five of 6 patients developed multiple new lesions at distant, noncontiguous central nervous system parenchymal sites during or after two to four cycles.
Median survival was 8.5 months for all 6 enrolled patients and 16.5 months for the 4 patients who completed craniospinal radiotherapy.

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Implication

A clinical study reveals rapid local tumor shrinkage alongside distant brain relapse with CHOP in primary central nervous system lymphoma, highlighting drug resistance.

Cite This Study

Lachance et al. (1994) studied this question.

synapsesocial.com/papers/6a898511de8e7079c6f7d473 https://doi.org/10.1212/wnl.44.9.1721

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Implication

A clinical study reveals rapid local tumor shrinkage alongside distant brain relapse with CHOP in primary central nervous system lymphoma, highlighting drug resistance.

Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma

Key Points

Discussion

Implication

Cite This Study

Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma

Key Points

Discussion

Implication

Cite This Study

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