Christine E. McLaren, Gary M. Brittenham, Victor R. Gordeuk, Margaret A. Hughes, Louise J. Keating, Statistical Modelling of the Distribution of Red Blood Cell Volumes in Iron Deficiency Anemia Using the Expectation-Maximisation Algorithm, Journal of the Royal Statistical Society. Series D (The Statistician), Vol. 35, No. 2, Special Issue: Statistical Modelling (1986), pp. 135-142
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McLaren et al. (1986) studied this question.
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