Two general approaches described are for enhancing the selectivity of the complexation of alkylammonium cations by crown ethers. The first involves the introduction of steric barriers in a monocyclic system and the second involves the use of bridges and macropolycyclic systems. The extent of molecular recognition by these host molecules and the effects of structural rigidity and flexibility are discussed.
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Ian O. Sutherland (1986) studied this question.
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