Key result
Infection of human astrocytes with picornaviruses selectively induces IL-8 and MCP-1 expression, which requires the activation of both AP-1 and NF-κB transcription factors.
Population
Primary human astrocytes, human astrocytoma cell line (U-373MG), and primary mouse astrocytes.
Comparison
Infection with picornaviruses. vs Uninfected cells or cells exposed to…
Design
Preclinical
Authors
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Does not support clinical translation; leaves open species-specific AP-1/NF-κB roles in human astrocyte responses to picornaviruses.
Picornavirus infection selectively induces IL-8 and MCP-1 in human astrocytes via AP-1 and NF-κB pathways, highlighting species-specific differences in neuroinflammatory responses compared to mice.
Kwon et al. (2003) studied Picornavirus infection (in vitro). Picornavirus infection (TMEV, CVB3, CVB4) vs. Mock infection or UV-inactivated virus was evaluated on Expression of IL-8 and MCP-1 genes and proteins. Infection of human astrocytes with picornaviruses selectively induces IL-8 and MCP-1 expression, which requires the activation of both AP-1 and NF-κB transcription factors.
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