The serum of patients with systemic lupus erythematosus may contain antibodies reacting in a variety of ways against several intracellular antigens. This report describes a new method of analyzing these antigen‐antibody reactions by immunoelectrophoresis on cellulose acetate membranes. The results show that abnormal sera may contain at least two different precipitating antibodies, one directed against a deoxy‐ribonucleohistone complex, and the other directed against an antigen that may be histone not attached to DNA.
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William A. Atchley (1961) studied this question.
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