Man toTrypanosome: The tubulin tyrosination/detyrosination cycle revisited

http://www.chem.qmw.ac.uk/iubmb/nomenclature/) is tyrosination.It uses this in listing EC 6.3.2.25, tubulin-tyrosine ligase (see http:// www.chem.qmw.ac.uk/iubmb/enzyme/).Bulinski and Gundersen [1986] give the arguments for preferring this term, based on the recommendations on naming derivatives of amino acids (see entries 3AA-1, 3AA-9.3, and 3AA-10.3 in http://www.chem.qmw.ac.uk/ iupac/AminoAcid /).Briefly, Tyrosylation would be misleading, since "tyrosyl" is the name of the acyl group, e.g., an N-terminal tyrosine residue, and acylation would suggest adding at the N-terminus.Tyrosinylation has almost the same implications, as it looks so like "tyrosyl."Tyrosinolation would also be misleading, as "tyrosinol" is defined as the alcohol in formed by reducing the -COOH of tyrosine to -CH 2 OH.Tyrosine ligation is also acceptable since TTL essentially carries out a ligation reaction.This work is dedicated to the memory of