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Novocaine was immobilized on BIOZANR after activation with dicyclohexylcarbodiimide. Under the optimum coupling conditions described (temperature, reagent concentration) a reaction product with novocaine content of 37% was obtained. Penicillin G was then bound to the BIOZAN‐novocaine complex resulting in an antibiotic with prolonged action and high water solubility. Penicillin G is continuously released after hydrolysis in acid and basic media.
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Dumitriu et al. (1986) studied this question.
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