Exhaustive Exercise-Induced Neutrophil-Associated Tissue Damage and Possibility of its Prevention

Neutrophils and inflammatory cytokines that accumulate in tissues often cause organ damage/dysfunctions. Herein, background information on some research findings of exertional effects on systemic inflammation centered on neutrophils is introduced. Furthermore, a functional activity measurement system of neutrophils including cell migration and reactive oxygen species (ROS) production, and preventive countermeasures against neutrophilinduced pathogenesis (e.g., polyphenols) are described.