July 1, 1995Journal of Magnetic Resonance Imaging
Clearance of gadolinium chelates by hemodialysis: An in vitro study
Authors
Discussion
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Implication
In vitro study demonstrates lower hemodialysis clearance rates for gadolinium chelates compared to urea, indicating extended dialysis sessions are required for elimination.
Key Points
- To establish in vitro hemodialysis clearance rates for clinically approved gadolinium chelates and determine rational strategies for their removal.
- Diluted Gd-DTPA, Gd-HP-DO3A, and Gd-DTPA-BMA separately in plasma and saline, testing dialysis through a clinical dialyzer unit with a capillary filter at flow rates of 0 to 300 cc/min.
- Measured predialyzer and postdialyzer concentrations via inductively coupled atomic emission photometry and compared results against standard urea and creatinine clearance rates.
- At 300 cc/min flow rates, clearance rates were 74 cc/min (95% CI, 68–80) for Gd-DTPA, 67 cc/min (95% CI, 63–71) for Gd-HP-DO3A, and 67 cc/min (95% CI, 63–71) for Gd-DTPA-BMA, compared to 180 cc/min (95% CI, 178–181) for urea and 142 cc/min (95% CI, 124–131) for creatinine.
- Clearance rates did not differ between saline and plasma, indicating an absence of protein binding.
- Kinetic modeling indicates that 12.2 to 14.7 hours of dialysis are required to remove 97% of the injected gadolinium chelate dose.
Cite This Study
Choyke et al. (1995) studied this question.