Synthesis and antibacterial screening of new 4‐((5‐(difluoromethoxy)‐1H‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinoline derivatives

Abstract magnified image A method for the synthesis of previously unknown heterocyclic systems 4‐((5‐(difluoromethoxy)‐1H‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinolines derivatives 6 has been developed based on various substitutes 2‐chloroquinoline‐3‐carbaldehydes 1 via the consecutive steps of conversion into tetrazolo[1,5‐a]quinoline‐4‐carbaldehyde 2 on treatment with sodium azide which upon reduction to the corresponding alcohol derivatives 3, conversion to chlorides 4 with thionyl chloride followed by the coupling with 5‐(difluoromethoxy)‐1H‐benzo[d]imidazole‐2‐thiol 5. The synthesized titled compounds (6a, 6b, 6c, 6d, 6e) were screened for the antibacterial activity against gram positive and gram negative bacteria. J. Heterocyclic Chem., (2010).