Production of Antibody in Patients with Uremia

THE reasons for rejection of homotransplants of renal and other tissues are not defined exactly, although there is considerable evidence that lack of success with this procedure is related in part to the production of antibody to the graft by the recipient.1 , 2 Whether such a cytotoxic substance is freely circulating in the blood or whether rejection may be the result of the development of a delayed type of hypersensitivity state has been the subject of many investigations. The available evidence is controversial; however, there is much to suggest that intracellular antibody may have a prominent role in bringing about rejection . . .