When SV40 is injected into neonatal or weanling hamsters, it induces a variety of malignant tumors (Eddy et al. 1962; Eddy 1964; Diamondopoulos 1973). The initial event in this process is thought to be the transformation of a single cell by a single virus particle. This transformation event can be observed in vitro by use of a number of selective assays (Todaro et al. 1964; Macpherson and Montagnier 1964; Stoker 1968; Smith et al. 1971) in cells from several species of mammals (Shein and Enders 1962; Rabson and Kirschstein 1962; Black and Rowe 1963; Diderholm et al. 1966).
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Risser et al. (1974) studied this question.