Structure–Function Relationships Determining Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome

Editorial| February 2024 Structure–Function Relationships Determining Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome This article has an Audio Podcast Kathleen M. Capaccione, M.D., Ph.D.; Kathleen M. Capaccione, M.D., Ph.D. 1Department of Radiology, Columbia University Irving Medical Center, New York, New York. Search for other works by this author on: This Site PubMed Google Scholar Marcos F. Vidal Melo, M.D., Ph.D. Marcos F. Vidal Melo, M.D., Ph.D. 2Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Accepted for publication October 16, 2023. This editorial accompanies the article on p. 251. This article has a related Infographic on p. A17. Address correspondence to Dr. Vidal Melo: Anesthesiology February 2024, Vol. 140, 186–188. https://doi.org/10.1097/ALN.0000000000004820 Connected Content Article: Causes of Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome: A Combined Multiple Inert Gas Elimination Technique and Dual-energy Computed Tomography Study Infographic: Got the Blues? Mechanisms of Hypoxemia in COVID-19 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Kathleen M. Capaccione, Marcos F. Vidal Melo; Structure–Function Relationships Determining Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome. Anesthesiology 2024; 140:186–188 doi: https://doi.org/10.1097/ALN.0000000000004820 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: covid-19, hypoxemia, respiratory distress syndrome, adult Thousands of papers appear when the words "COVID-19" and "hypoxemia" are entered in a cursory PubMed search, yet a quantitative understanding of the functional impairment leading to hypoxemia during COVID-19 has not been established. In this issue of Anesthesiology, Busana et al.1 provide novel data on fundamental physiologic factors producing hypoxemia in patients with COVID-19 acute respiratory distress syndrome (ARDS) using two sophisticated methods to study respiratory physiology: the multiple inert gases elimination technique (MIGET) combined with imaging data from dual-energy computed tomography (DECT). Early in medical school, we learn that the four physiologic determinants of hypoxemia are hypoventilation, diffusion impairment, right-to-left shunt, and alveolar ventilation to perfusion (⁠V·A/Q·T⁠) mismatch.2 For comprehensiveness, diffusion-to-perfusion mismatch can be added as a fifth.3,4 We further learn that V·A/Q·T mismatch is the... You do not currently have access to this content.