Key result
Vitamin D improves diabetic cardiomyopathy by suppressing NOX4/NLRP3-mediated pyroptosis.
Supports hypothesis generation for vitamin D in DCM; leaves open clinical translation of pyroptosis inhibition.
Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, for which effective treatment options remain unavailable. Recent studies have demonstrated that vitamin D exerts protective effects against DCM, but its role in alleviating cellular pyroptosis remains uncertain. The present study aimed to investigate the ameliorative effects of vitamin D on pyroptosis in DCM and to elucidate the underlying molecular mechanisms. In the
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Wang et al. (2025) studied Diabetic cardiomyopathy. Vitamin D was evaluated on Cellular pyroptosis and molecular mechanisms. Vitamin D improves diabetic cardiomyopathy by inhibiting pyroptosis through the NOX4/NLRP3 inflammasome pathway.
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