An ion-pair high performance liquid chromatographic (HPLC) method was developed for quantitating aspirin (ASA) and its major metabolites (salicylic acid (SA), gentisic acid (GA) and salicyluric acid (SU)) in human plasma. The average extraction recovery for ASA and its metabolites was greater than 90%. The limit of sensitivity of this assay was 0.5, 0.05, 0.1 and 0.05 μg/ml for GA, SU, SA and ASA, respectively. The method gave high reproducibility with coefficients of variation less than 10%. This method has been used for monitoring SA and ASA levels in preeclamptic patients after administration of low dose aspirin.
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Shen et al. (1990) studied this question.
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